6-Trifluoromethyl pyrimidin-4-ylamine

Base Information

• Chemical Name: 6-Trifluoromethyl pyrimidin-4-ylamine
• CAS No.: 672-41-3
• Molecular Formula: C5H4 F3 N3
• Molecular Weight: 163.102
• Hs Code.: 2933599090
• Mol file: 672-41-3.mol

Synonyms:Pyrimidine,4-amino-6-(trifluoromethyl)- (6CI,8CI); 4-Amino-6-(trifluoromethyl)pyrimidine;6-(Trifluoromethyl)-4-pyrimidinamine

Chemical Property of 6-Trifluoromethyl pyrimidin-4-ylamine

Chemical Property:

• Boiling Point: 231.9±40.0 °C(Predicted)
• PKA: 2.21±0.10(Predicted)
• PSA: 80.48000
• Density: 1.460±0.06 g/cm3(Predicted)
• LogP: 1.53510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-(Trifluoromethyl)pyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Trifluoromethyl pyrimidin-4-ylamine

There total 6 articles about 6-Trifluoromethyl pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-6-(trifluoromethyl)pyrimidine (37552-81-1) → 4-amino-6-(trifluoromethyl)pyrimidine (672-41-3)

Guidance literature:

With ammonia; In water; acetonitrile; at 25 ℃; for 12h;

Reference yield: 61.3%

6-trifluoromethyl-4-hydroxypyrimidine (1546-78-7) + ammonia (7664-41-7) → 4-amino-6-(trifluoromethyl)pyrimidine (672-41-3)

Guidance literature:

6-trifluoromethyl-4-hydroxypyrimidine; With oxalyl dichloride; N,N-dimethyl-formamide; In ethyl acetate; for 2h; Reflux;

ammonia; In methanol; at 70 ℃; for 15h; Sealed tube;

Reference yield: 14.0%

6-trifluoromethyl-4-hydroxypyrimidine (1546-78-7) → 4-amino-6-(trifluoromethyl)pyrimidine (672-41-3)

Guidance literature:

6-trifluoromethyl-4-hydroxypyrimidine; With trichlorophosphate; for 7h; Heating / reflux;

With ammonia; In water; at 20 ℃;

upstream raw materials:

4-trifluoromethyl-1,6-dihydropyrimidine-6-oxide

4-amino-6-trifluoromethyl-1H-pyrimidine-2-thione

4-chloro-6-(trifluoromethyl)pyrimidine

2-sulfanylidene-6-(trifluoromethyl)-2,3-dihydropyrimidin-4(1H)-one

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