4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

Base Information

Chemical Name:4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride
CAS No.:1000030-01-2
Molecular Formula:C₂₃H₃₄F₃N₃O₂*ClH
Molecular Weight:477.998
Hs Code.:

Synonyms:4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

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Chemical Property of 4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

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Technology Process of 4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

There total 1 articles about 4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 76835-14-8
1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride

: 147699-19-2
tert-butyl 4-{2-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate

: 1000030-01-2
4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

Guidance literature:: With potassium carbonate; In acetonitrile; Heating / reflux;

Reference yield: 100.0%

: 1000030-01-2
4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

: 1-(2-piperidin-4-ylethyl)-4-(3-trifluoromethylphenyl)piperazine dihydrochloride

Guidance literature:: With hydrogenchloride; In methanol; water; ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 1000030-01-2
4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]-ethyl}piperidine-1-carboxylic acid tert-butyl ester hydrochloride

: 1-(4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-piperidin-1-yl)propan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; water; ethyl acetate / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

With hydrogenchloride; potassium carbonate; In methanol; water; ethyl acetate; acetonitrile;