1-BOC-4-(2-METHANESULFONYLOXY-ETHYL)-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(2-METHANESULFONYLOXY-ETHYL)-PIPERIDINE
• CAS No.: 147699-19-2
• Molecular Formula: C13H25NO5S
• Molecular Weight: 307.411
• Hs Code.: 2933399090
• Mol file: 147699-19-2.mol

Synonyms:t-butyl 4-(2-((methylsulfonyl)oxy)ethyl)-1-piperidinecarboxylate;tert-butyl 4-(2-((methylsulfonyl)oxy)ethyl)piperidine-1-carboxylate;1-(1-tert-Butyloxycarbonyl-piperidin-4-yl)-2-methanesulphonyloxyethane;2-(1-tert-Butoxycarbonylpiperid-4-yl)ethyl methanesulfonate;1-N-BOC-4-(2-METHANESULFONYLOXYETHYL)PIPERIDINE;tert-butyl 4-[2-(methanesulfonyloxy)ethyl]piperidine-1-carboxylate;N-t-butoxycarbonyl-4-piperidylethyl methanesulfonate;1-tert-butyloxycarbonyl-4-[2-(methanesulfonyloxy)ethyl]-piperidine;1-Boc-4-(2-(methylsulfonyloxy)ethyl)piperidine;

Chemical Property of 1-BOC-4-(2-METHANESULFONYLOXY-ETHYL)-PIPERIDINE

Chemical Property:

• Boiling Point: 431.1±18.0 °C(Predicted)
• PKA: -1.54±0.40(Predicted)
• PSA: 81.29000
• Density: 1.154±0.06 g/cm3(Predicted)
• LogP: 3.01850
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

1-N-Boc-4-(2-methanesulfonyloxyethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(2-METHANESULFONYLOXY-ETHYL)-PIPERIDINE

There total 11 articles about 1-BOC-4-(2-METHANESULFONYLOXY-ETHYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (89151-44-0) → tert-butyl 4-{2-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate (147699-19-2)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-{2-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate (147699-19-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 0 °C

2: H₂ / Pd/C / methanol / 20 °C

3: LAH / tetrahydrofuran / 20 °C

4: NEt₃ / tetrahydrofuran / 0 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(03)00350-0

Reference yield:

di-isopropyl ether (108-20-3) + methanesulfonyl chloride (124-63-0) + 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester (89151-44-0) → tert-butyl 4-{2-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate (147699-19-2)

Guidance literature:

With triethylamine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane;

upstream raw materials:

methanesulfonyl chloride

4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Downstream raw materials:

4-(4-chlorobenzoyl)-1-[2-(4-piperidinyl)ethyl]-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on

MPC-3100

Refernces

• 1、 Borkin, Dmitry,Klossowski, Szymon,Pollock, Jonathan,Miao, Hongzhi,Linhares, Brian M.,Kempinska, Katarzyna,Jin, Zhuang,Purohit, Trupta,Wen, Bo,He, Miao,Sun, Duxin,Cierpicki, Tomasz,Grembecka, Jolanta. "Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction". . p. 4832 - 4850. Retrieved 2018.
• 2、 -. "N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES". Page/Page column 99. . Retrieved 2019/10/23.
• 3、 -. "Piperidine amino derivative and application thereof in fighting schizophrenia". Paragraph 0169; 0173. . Retrieved 2018/03/25.