1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)

Base Information

• Chemical Name: 1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)
• CAS No.: 76835-14-8
• Molecular Formula: C₁₁H₁₃F₃N₂*(x)ClH
• Molecular Weight: 266.6904696
• Mol file: 76835-14-8.mol

Synonyms:

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Chemical Property of 1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)

Chemical Property:

• PSA: 15.27000
• LogP: 4.11280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 1-(3-Trifluoromethylphenyl)piperazine (TFMPP) is an entactogenic drug which selectively promotes the release of serotonin. When used in combination with 1-benzylpiperazine, TFMPP increases both serotonin and dopamine, mirroring the effects of 3,4-methylenedioxymethamphetamine. Drug-drug synergism may induce seizures. TFMPP has been identified in party pills and powders. Its metabolism in rats has been described. This product is intended for forensic applications.

Technology Process of 1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)

There total 2 articles about 1-(m-Trifluoromethylphenyl) piperazine (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 3-trifluoromethylaniline (98-16-8) → 1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride (76835-14-8)

Guidance literature:

With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;

DOI:10.1016/j.bmc.2016.09.005

Reference yield:

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 3-trifluoromethylaniline (98-16-8) → 1-(3-trifluoromethylphenyl)piperazine hydrochloride (76835-14-8)

Guidance literature:

With potassium carbonate; In butan-1-ol; at 150 ℃; for 0.5h; Microwave irradiation;

DOI:10.1080/14756366.2020.1759582

Reference yield:

1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride (76835-14-8) → BIMT 17 hydrochloride (147359-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / acetone / 4 h / 20 - 60 °C / Large scale

2.1: thionyl chloride / 1,2-dichloro-ethane / 4 h / 20 - 80 °C / Large scale

3.1: potassium carbonate / dimethyl sulfoxide / 8 h / 58 °C / Large scale

3.2: 2 h / 65 °C / Large scale

With thionyl chloride; potassium carbonate; sodium hydroxide; In dimethyl sulfoxide; 1,2-dichloro-ethane; acetone;

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

3-trifluoromethylaniline

Downstream raw materials:

1-{2-[4-(3-trifluoromethylphenyl)piperazine-1-yl]ethyl}-1,5,6,7-tetrahydroindol-4-one

trans-4-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}cyclo-hexylamine

1-[2-(1,4-dioxaspiro[4.5]dec-8-yl)ethyl]-4-(3-trifluoromethylphenyl)piperazine

BIMT 17 hydrochloride