2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

Base Information

Chemical Name:2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole
CAS No.:135430-12-5
Molecular Formula:C₂₃H₂₂N₄O₃S₂
Molecular Weight:466.585
Hs Code.:

Synonyms:2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

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Chemical Property of 2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

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Technology Process of 2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

There total 5 articles about 2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: [(2-Chloromethyl-4-methyl-thiophen-3-ylcarbamoyl)-methyl]-carbamic acid benzyl ester

: 134469-07-1
Benzimidazol-2-thiol

: 135430-12-5
2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 17h; Ambient temperature;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 15050-24-5
N-(benzyloxycarbonyl)glycyl chloride

: 135430-12-5
2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 99.3 percent / hexamethylphosphoric acid triamide; acetonitrile / Ambient temperature

2: 81.3 percent / LiBH₄ / tetrahydrofuran / 96 h / Ambient temperature

3: SOCl₂ / benzene / 80 °C

4: 80.2 percent / K₂CO₃ / dimethylformamide / 17 h / Ambient temperature

With lithium borohydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 135429-74-2
3-((benzyloxycarbonyl)glycyl)amino-2-hydroxymethyl-4-methylthiophene

: 135430-12-5
2-<(((3-(benzyloxycarbonyl)glycyl)amino-4-methylthiophen-2-yl)methyl)thio>-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 80 °C

2: 80.2 percent / K₂CO₃ / dimethylformamide / 17 h / Ambient temperature

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/0223-5234(91)90024-H