4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide

Base Information

• Chemical Name: 4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide
• CAS No.: 1037078-38-8
• Molecular Formula: C₃₁H₃₂BrN₅O₄
• Molecular Weight: 618.53

Synonyms:4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide

Chemical Property of 4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide

Chemical Property:

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Technology Process of 4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide

There total 1 articles about 4-bromo-N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(+)-(4'S)-2-(4'-isopropyl-3',4'-dihydrooxazol-2'-yl)aniline (209850-73-7) + 4-bromopyridine-2,6-dicarbonyl dibromide (120491-93-2) → 4-bromo-N2,N6-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide (1037078-38-8)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 12h; Molecular sieve; Inert atmosphere;

DOI:10.1021/ja802308a

Reference yield:

2,2'-bis(benzyloxy)biphenyl-3,3'-diyldiboronic acid (1086433-64-8) + 4-bromo-N2,N6-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide (1037078-38-8) → 4,4'-(2,2'-bis(benzyloxy)biphenyl-3,3'-diyl)bis(N2,N6-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide) (1037078-42-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 24h; Reflux; Inert atmosphere;

DOI:10.1021/ja802308a

Reference yield:

4-bromo-N2,N6-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide (1037078-38-8) + (R)-2,2'-bis(benzyloxy)-1,1'-binaphthyl-3,3'-diyldiboronic acid → 4,4'-((R)-2,2'-bis(benzyloxy)-1,1'-binaphthyl-3,3'-diyl)bis(N2,N6-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 24h; Reflux; Inert atmosphere;

DOI:10.1021/ja802308a

upstream raw materials:

(+)-(4'S)-2-(4'-isopropyl-3',4'-dihydrooxazol-2'-yl)aniline

4-bromopyridine-2,6-dicarbonyl dibromide

Downstream raw materials:

4,4'-(2,2'-bis(benzyloxy)biphenyl-3,3'-diyl)bis(N₂,N₆-bis(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)phenyl)pyridine-2,6-dicarboxamide)

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