209850-73-7Relevant articles and documents
The role of the achiral template in enantioselective transformations. Radical conjugate additions to α-methacrylates followed by hydrogen atom transfer
Sibi, Mukund P.,Sausker, Justin B.
, p. 984 - 991 (2002)
We have evaluated various achiral templates (1a-g, 10, and 16) in conjunction with chiral Lewis acids in the conjugate addition of nucleophilic radicals to α-methacrylates followed by enantioselective H-atom transfer. Of these, a novel naphthosultam templ
Development of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides
Guo, Rui,Sang, Jiale,Xiao, Haijing,Li, Junxia,Zhang, Guozhu
, p. 1337 - 1345 (2022/03/27)
A new set of stereochemically diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphaneyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic molecules has also been realized for the first time.
Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination
Chang, Xihao,Zhang, Qinglin,Guo, Chang
supporting information, p. 4915 - 4918 (2019/06/27)
Asymmetric assembly of atropisomeric anilines from abundant and readily available precursors is one of the most challenging but valuable processes in organic synthesis. The use of highly efficient Smiles rearrangement to accomplish switchable enantioselec
