109-61-5

Basic information

• Product Name: Propyl chloroformate
• Synonyms: Formicacid, chloro-, propyl ester (6CI,7CI,8CI);Propyl carbonochloridate;Propylchlorocarbonate;Chlorocarbonicacidpropylester
• CAS NO: 109-61-5
• Molecular Formula: C₄H₇ClO₂
• Molecular Weight: 122.55018
• EINECS: 203-687-7
• Mol File: 109-61-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 116.2 °C at 760 mmHg
• Flash Point: 29.1 °C
• Appearance: colorless liquid
• Density: 1.119 g/cm³
• Vapor Pressure: 18.4mmHg at 25°C
• Refractive Index: 1.411
• CAS DataBase Reference: Propyl chloroformate(CAS DataBase Reference)
• NIST Chemistry Reference: Propyl chloroformate(109-61-5)
• EPA Substance Registry System: Propyl chloroformate(109-61-5)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R10:; R23:; R34:
• Safety Statements: S26:; S36:; S45:
• RIDADR: 2740
• HazardClass: 6.1
• PackingGroup: I
• Hazardous Substances Data: 109-61-5(Hazardous Substances Data)

Usage

General Description

Propyl chloroformate is a chemical compound with the formula C4H8Cl2O2. It is a colorless liquid with a pungent odor, commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and functional materials. Propyl chloroformate is a versatile reagent that can be used for the protection of alcohols and amines in organic synthesis. It is also used in the production of dyes, perfumes, and other chemicals. However, propyl chloroformate is highly reactive and can cause irritation to the skin, eyes, and respiratory system, and should be handled with caution in a well-ventilated area and with appropriate personal protective equipment.

InChI:InChI=1/C4H7ClO2/c1-2-3-7-4(5)6/h2-3H2,1H3

Upstream product

• 71-23-8 propan-1-ol 
• 75-44-5 phosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 503-38-8 trichloromethyl chloroformate 
• 67-66-3 chloroform 

Downstream Products

• 94257-17-7 3-phenyl-7-propoxycarbonylamino-coumarin 
• 37653-84-2 4-[(propoxycarbonyl)amino]benzoic acid 
• 27822-60-2 (1-methyl-2-phenyl-ethyl)-carbamic acid propyl ester 
• 5532-90-1 n-propyl N-phenylcarbamate 
• 2610-69-7 (3-chloro-phenyl)-carbamic acid propyl ester 
• 623-96-1 Dipropyl carbonate 
• 38577-26-3 3β-propyloxycarbonyloxycholestene-5 
• 85590-63-2 N-propoxycarbonyl-phenylalanine 
• 99060-91-0 carbonic acid-(2-nitro-phenyl ester)-propyl ester 
• 860555-71-1 1-benzoylamino-2-propoxycarbonyloxy-benzene 
• 187737-37-7 propene 
• 78-75-1 1,2-Dibromopropane 
• 627-12-3 1-propyl carbamate 
• 54662-02-1 propyl carbazate 

Related news

Determination of efficacy of fingermark enhancement reagents; the use of Propyl chloroformate (cas 109-61-5) for the derivatization of fingerprint amino acids extracted from paper☆08/21/2019

The analysis of the constituents of fingerprints has been described numerous times, mainly with the purpose of determining the aging effect on fingerprints or showing the differences between donors or groups of donors. In this paper we describe the use of derivatized amino acids to determine the...detailed

Relevant articles and documents

Photo-on-Demand Synthesis of Chloroformates with a Chloroform Solution Containing an Alcohol and Its One-Pot Conversion to Carbonates and Carbamates

Chloroformates are key reagents for synthesizing carbonates and carbamates. The present study reports a novel photo-on-demand in situ synthesis of chloroformates with a CHCl3 solution containing a primary alkyl alcohol. It further allowed the one-pot synthesis of carbonates and carbamates through subsequent addition of alcohols or amines, respectively.

In vitro radical scavenging and cytotoxic activities of novel hybrid selenocarbamates

Novel selenocyanate and diselenide derivatives containing a carbamate moiety were synthesised and evaluated in vitro to determine their cytotoxic and radical scavenging properties. Cytotoxic activity was tested against a panel of human cell lines including CCRF-CEM (lymphoblastic leukaemia), HT-29 (colon carcinoma), HTB-54 (lung carcinoma), PC-3 (prostate carcinoma), MCF-7 (breast adenocarcinoma), 184B5 (non-malignant, mammary gland derived) and BEAS-2B (non-malignant, derived from bronchial epithelium). Most of the compounds displayed high antiproliferative activity with GI50 values below 10 μM in MCF-7, CCRF-CEM and PC-3 cells. Radical scavenging properties of the new selenocompounds were confirmed testing their ability to scavenge DPPH and ABTS radicals. Based on the activity of selenium-based glutathione peroxidases (GPxs), compounds 1a, 2e and 2h were further screened for their capacity to reduce hydrogen peroxide under thiol presence. Results suggest that compound 1a mimics GPxs activity. Cytotoxic parameters, radical scavenging activity and ADME profile point to 1a as promising drug candidate.

NOVEL DITHIOLOPYRROLONES AND THEIR THERAPEUTICAL APPLICATIONS

The present invention provides novel dithiolopyrrolone compounds and their salts, which promote production of white blood cells and are useful as prevention and treatments for microbial infections such as HIV infection and blood disorders such as neutropenia and other related diseases. The present invention also provides therapeutic compositions comprising particularly useful types of dithiolopyrrolones, the salts thereof, and methods and use in the manufacture of a medication for treatment of diseases.