2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester

Base Information

• Chemical Name: 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester
• CAS No.: 94797-12-3
• Molecular Formula: C₁₈H₁₆ClNO₄
• Molecular Weight: 345.782

Synonyms:2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester

Chemical Property of 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester

There total 5 articles about 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

TA-1801 (88352-44-7) + methyl iodide (74-88-4) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester (94797-12-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; paraffin; 1.) -15 deg C, 2.) room temperature, 5 h;

DOI:10.1021/jm00401a021

Reference yield:

(furan-2-ylcarbonyl)methylamine hydrochloride (88352-86-7) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester (94797-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

4: 88 percent / NaH / paraffin; dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 2.) room temperature, 5 h

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1021/jm00401a021

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid ethyl ester (94797-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / NaHCO₃ / H₂O; ethyl acetate / Ambient temperature

2: 70 percent / NaH / paraffin; dimethylformamide / 1.) -50 - -40 deg C, 20 min, 2.) -40 to 10 deg C, 30 min

3: 86 percent / phosphoryl chloride / dimethylformamide / 8 h / Ambient temperature

4: 88 percent / NaH / paraffin; dimethylformamide; tetrahydrofuran / 1.) -15 deg C, 2.) room temperature, 5 h

With sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1021/jm00401a021

upstream raw materials:

TA-1801

methyl iodide

(furan-2-ylcarbonyl)methylamine hydrochloride

4-chloro-benzoyl chloride

Downstream raw materials:

2-[2-(4-Chloro-phenyl)-5-furan-2-yl-oxazol-4-yl]-propionic acid

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