(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

Base Information

Chemical Name:(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one
CAS No.:122651-62-1
Molecular Formula:C₂₀H₃₀O₅S
Molecular Weight:382.521
Hs Code.:

(R<sub>S</sub>)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

Synonyms:(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

Suppliers and Price of (R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

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Technology Process of (R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

There total 1 articles about (R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

: 96-48-0
4-butanolide

: 99277-36-8
(R_s)-1-(tetrahydropyran-2-yl)oxy-4-<(p-tolyl)sulfinyl>butane

: 122651-62-1
(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

Guidance literature:: With lithium diethylamide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1248/cpb.36.4785

Reference yield: 81.0%

: 108-24-7
acetic anhydride

: 122651-62-1
(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

: 122629-84-9
(R_S)-1-acetoxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

Guidance literature:: In pyridine; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.36.4785

Reference yield:

: 122651-62-1
(R_S)-1-hydroxy-8-(tetrahydropyran-2-yl)oxy-5-(p-tolyl)sulfinyloctan-4-one

: 112996-18-6
(R_S)-3,4-dihydro-5-(p-tolyl)sulfinyl-2H-pyran-6-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / pyridine / 0.5 h / Ambient temperature

2: pyridinium p-toluenesulfonate / methanol / 6 h / 50 °C

3: p-toluenensulfonic acid / benzene / 12 h / Ambient temperature

4: 92.4 percent / K₂CO₃, H₂O / methanol / 6 h / Ambient temperature

With water; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; In pyridine; methanol; benzene;
DOI:10.1248/cpb.36.4785