1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

Base Information

• Chemical Name: 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate
• CAS No.: 253197-80-7
• Molecular Formula: C₁₃H₁₆F₆O₃
• Molecular Weight: 334.259

Synonyms:1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

Chemical Property of 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

There total 2 articles about 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1,1,1,3,3,3-hexafluoroisopropyl acrylate (2160-89-6) + cyclohexanecarbaldehyde (2043-61-0) → (2S,6R)-2,6-dicyclohexyl-5-methylene-1,3-dioxan-4-one + (2R,6R)-2,6-dicyclohexyl-5-methylene-1,3-dioxan-4-one + (2S,6S)-2,6-dicyclohexyl-5-methylene-1,3-dioxan-4-one + 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate (253197-80-7)

Guidance literature:

With (3R,8R,9S)-10,11-dihydro-3,9-epoxy-6'-hydroxy-cinchonane; In N,N-dimethyl-formamide; at -55 ℃; for 19h; Further byproducts given;

DOI:10.1016/j.tet.2005.09.072

Reference yield: 31.0%

1,1,1,3,3,3-hexafluoroisopropyl acrylate (2160-89-6) + cyclohexanecarbaldehyde (2043-61-0) → 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate (253197-80-7)

Guidance literature:

With (3R,8R,9S)-10,11-dihydro-3,9-epoxy-6'-hydroxy-cinchonane; In N,N-dimethyl-formamide; at -55 ℃; for 72h;

DOI:10.1021/ja992655+

Reference yield:

methanol (67-56-1) + 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate (253197-80-7) → methyl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

Guidance literature:

With triethylamine; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2005.09.072

upstream raw materials:

1,1,1,3,3,3-hexafluoroisopropyl acrylate

cyclohexanecarbaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 253197-80-7 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-cyclohexyl-3-hydroxy-2-methylenepropanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send