3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine

Base Information

• Chemical Name: 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine
• CAS No.: 78635-93-5
• Molecular Formula: C₄₁H₄₃N₆O₇P
• Molecular Weight: 762.802

Synonyms:3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine

Chemical Property of 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine

Chemical Property:

Purity/Quality:

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Technology Process of 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine

There total 1 articles about 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N⁶-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Chloro-(N,N-dimethylamino)-methoxyphosphine (70063-12-6) + N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (64325-78-6) → 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N6-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine (78635-93-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; for 0.25h; Ambient temperature;

DOI:10.1016/S0040-4039(01)90461-7

Reference yield: 74.0%

N4-Anisoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-42-0) + 3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N6-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine (78635-93-5) → N6-Benzoyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'-5')-P-methoxy-phosphino-N4-anisoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 0.25h; ice bath;

DOI:10.1021/jo00199a032

Reference yield: 66.6%

3'-O-<(N,N-Dimethylamino)methoxyphosphino>-N6-benzoyl-5'-O-(dimethoxytrityl)-2'-deoxyadenosine (78635-93-5) + N4-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (51549-37-2) → N6-Benzoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'5')-N4-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine (93134-48-6)

Guidance literature:

With 1H-tetrazole; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1021/jo00199a032

upstream raw materials:

Chloro-(N,N-dimethylamino)-methoxyphosphine

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

Downstream raw materials:

C₅₄H₅₆N₇O₁₄P

4-Oxo-pentanoic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-({(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-methoxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

N⁶-Benzoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxyadenosyl-(3'5')-N⁴-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

C₅₆H₅₅N₈O₁₄P

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