(Dimethylamino)methyl phosphonochloridoite

Base Information

• Chemical Name: (Dimethylamino)methyl phosphonochloridoite
• CAS No.: 70063-12-6
• Molecular Formula: C3H9ClNOP
• Molecular Weight: 141.536421
• DSSTox Substance ID: DTXSID50592804
• Wikidata: Q82487116
• Mol file: 70063-12-6.mol

Synonyms:(Dimethylamino)methyl phosphonochloridoite;SCHEMBL1057523;DTXSID50592804;ARAKSJFGTUYKFI-UHFFFAOYSA-N;chloro-N,N-dimethylaminomethoxyphosphine;Chloro(N,N-dimethylamino)methoxyphosphine

Chemical Property of (Dimethylamino)methyl phosphonochloridoite

Chemical Property:

• PSA: 26.06000
• LogP: 1.26940
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 141.0110286
• Heavy Atom Count: 7
• Complexity: 43.9

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)COPCl

Technology Process of (Dimethylamino)methyl phosphonochloridoite

There total 2 articles about (Dimethylamino)methyl phosphonochloridoite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl dichlorophosphite (3279-26-3) + N,N-Dimethyltrimethylsilylamine (2083-91-2) → Chloro-(N,N-dimethylamino)-methoxyphosphine (70063-12-6)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ejoc.201000213

Reference yield: 71.0%

methyl dichlorophosphite (3279-26-3) + dimethyl amine (124-40-3) → Chloro-(N,N-dimethylamino)-methoxyphosphine (70063-12-6)

Guidance literature:

In diethyl ether; at -78 - 25 ℃; for 4h;

DOI:10.1016/S0040-4039(01)90461-7

Reference yield: 93.0%

Chloro-(N,N-dimethylamino)-methoxyphosphine (70063-12-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester (78635-91-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; for 0.25h; Ambient temperature;

DOI:10.1016/S0040-4039(01)90461-7

upstream raw materials:

methyl dichlorophosphite

dimethyl amine

N,N-Dimethyltrimethylsilylamine

Downstream raw materials:

Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester

N⁴-Anisoyl-P-methyl-5'-O-dimethoxytrityl-2'-deoxycytidyl-3'-O-<(N,N-dimethylamino)methoxy-phosphino>-(3'5')-N⁶-benzoyl-2'-deoxyadenosine

Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Dimethyl-phosphoramidous acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

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