(R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester

Base Information

• Chemical Name: (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester
• CAS No.: 137481-59-5
• Molecular Formula: C₁₈H₁₈F₃NO₄
• Molecular Weight: 369.34

Synonyms:(R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester

Chemical Property of (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester

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Technology Process of (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester

There total 4 articles about (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-Trifluoromethylbenzaldehyde (447-61-0) + acetoacetic acid methyl ester (105-45-3) → (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester (137481-59-5)

Guidance literature:

With ammonia; acetic acid; In ethanol; for 6h; Ambient temperature;

DOI:10.1002/ardp.2503241004

Reference yield: 47.0%

2-Trifluoromethylbenzaldehyde (447-61-0) + methyl 3-aminocrotonate (21731-17-9) → (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester (137481-59-5)

Guidance literature:

With acetic acid; In ethanol; for 24h; Ambient temperature;

DOI:10.1002/ardp.2503241004

Reference yield: 47.0%

2-Trifluoromethylbenzaldehyde (447-61-0) + methyl 3-aminocrotonate (21731-17-9) → (R,S)-1,2-Dihydro-4,6-dimethyl-3,5-dinitro-2-<2-(trifluormethyl)phenyl>-pyridin (137481-60-8) + (R,S)-1,2-Dihydro-4,6-dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester (137481-59-5)

Guidance literature:

With acetic acid; In ethanol; for 24h; Ambient temperature;

DOI:10.1002/ardp.2503241004

upstream raw materials:

2-Trifluoromethylbenzaldehyde

methyl 3-aminocrotonate

1-nitro-2-propanone

acetoacetic acid methyl ester

Downstream raw materials:

(R,S)-1,2,5,7-Tetrahydro-4-methoxymethyl-5-oxo-2-<2-(trifluormethyl)phenyl>-furo<3,4-b>pyridin-3-carbonsaeuremethylester

5,7-Dihydro-4-methyl-5-oxo-2-<(2-trifluoromethyl)phenyl>furo<3,4-b>pyridin-3-carbonsaeuremethylester

4,6-Dimethyl-2-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester

(R,S)-4-Brommethyl-1,2,5,7-tetrahydro-5-oxo-2-<2-(trifluormethyl)phenyl>-furo<3,4-b>pyridin-3-carbonsaeuremethylester

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