N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Base Information

Chemical Name:N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide
CAS No.:1410040-87-7
Molecular Formula:C₂₀H₁₇FN₆O₂
Molecular Weight:392.392
Hs Code.:

Synonyms:N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Chemical Property of N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

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Technology Process of N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

There total 6 articles about N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884494-34-2
2-ethynyl-5-fluoropyridine

: 1410040-82-2
N-[(3E)-3-(hydroxyimino)propyl]-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

: 1410040-87-7
N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: N-[(3E)-3-(hydroxyimino)propyl]-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Cooling with ice;

2-ethynyl-5-fluoropyridine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 15h; Cooling with ice;

Reference yield:

: 884494-34-2
2-ethynyl-5-fluoropyridine

: C₁₃H₁₄ClN₅O₂

: 1410040-87-7
N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h; Cooling with ice;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1410040-87-7
N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: water; hydrogenchloride / tetrahydrofuran / 1 h / 20 °C

3.1: sodium acetate; hydroxylamine hydrochloride / ethanol; water / 2 h / Cooling with ice

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 15 h / 20 °C / Cooling with ice

4.2: 15 h / 20 °C / Cooling with ice

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; water; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;