N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Base Information

Chemical Name:N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide
CAS No.:1410039-22-3
Molecular Formula:C₂₂H₂₁FN₆O₂
Molecular Weight:420.446
Hs Code.:

Synonyms:N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Suppliers and Price of N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

There total 7 articles about N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1410040-87-7
N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

: 75-03-6
ethyl iodide

: 1410039-22-3
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

ethyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1410039-22-3
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 3 h / 0 °C

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

6.2: 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; N-[(dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2015.01.044

Reference yield:

: 1410040-78-6
N-(3,3-diethoxypropyl)-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

: 1410039-22-3
N-ethyl-N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 18 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 3 h / 0 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

4.1: triethylamine / tetrahydrofuran / 16 h / 20 °C / Cooling with ice

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

5.2: 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2015.01.044