6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

Base Information

Chemical Name:6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone
CAS No.:212489-68-4
Molecular Formula:C₂₆H₃₀N₂O₉
Molecular Weight:514.532
Hs Code.:

Synonyms:6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

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Chemical Property of 6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

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Technology Process of 6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

There total 9 articles about 6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6,7-dimethoxy-2-morpholin-4-yl-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-isoquinoline-3-carboxylic acid

: 74-88-4
methyl iodide

: 212489-68-4
6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm000558h

Reference yield:

: 97081-13-5
3,4-dimethoxy-6-(3,4,5-trimethoxybenzoyl)benzoic acid

: 212489-68-4
6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 20 °C

2.1: 4 N HCl / ethyl acetate / 20 °C

2.2: AcOH / dioxane / 6 h / Heating

3.1: various solvent(s) / 100 °C

4.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: 5658-49-1
N,N-dimethyl(3,4,5-trimethoxyphenyl)carboxamide

: 212489-68-4
6,7-dimethoxy-3-methoxycarbonyl-2-morpholino-4-(3,4,5-trimethoxyphenyl)-1(2H)-isoquinolinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -40 °C

2.1: 2 N HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 6 h / Heating

6.1: various solvent(s) / 100 °C

7.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; recorcinol; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h