1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Base Information

Chemical Name:1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone
CAS No.:700376-28-9
Molecular Formula:C₃₇H₂₉N₅O
Molecular Weight:559.67
Hs Code.:

Synonyms:1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

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Chemical Property of 1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

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Technology Process of 1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

There total 9 articles about 1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 1-methyl-3-(2H-tetrazol-5-yl)-4-p-tolyl-1H-quinolin-2-one

: 700376-28-9
1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: 1-methyl-3-(2H-tetrazol-5-yl)-4-p-tolyl-1H-quinolin-2-one; With sodium hydroxide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.25h;

trityl chloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm031100t

Reference yield:

: 36192-63-9
2-amino-4'-methylbenzophenone

: 700376-28-9
1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 9 steps

1.1: CH₂Cl₂ / 1 h / 20 °C

2.1: NaH / ethanol / 2 h / Heating

3.1: tetrabutylammonium bromide; KOH / tetrahydrofuran; dimethylformamide / 0.17 h / 20 °C

3.2: 89 percent / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

4.1: NaOH / ethanol / Heating

5.1: SOCl₂ / 1 h / Heating

6.1: NH₃ / CH₂Cl₂ / 0.67 h

7.1: 0.59 g / POCl₃ / benzene / 7 h / Heating

8.1: p-toluenesulfonic acid monohydrate; trimethylstannylazide / xylene / 115 - 120 °C

9.1: aq. NaOH / CH₂Cl₂; tetrahydrofuran / 0.25 h / 20 °C

9.2: tetrahydrofuran; CH₂Cl₂ / 3 h / 20 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; tetrabutylammomium bromide; ammonia; sodium hydride; azidotrimethyltin; toluene-4-sulfonic acid; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; xylene; benzene;
DOI:10.1021/jm031100t

Reference yield:

: 700376-53-0
1,2-dihydro-4-(4-methylphenyl)-1-methyl-2-oxo-3-quinolinecarbonitrile

: 700376-28-9
1-methyl-4-(4-methylphenyl)-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-2(1H)quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: p-toluenesulfonic acid monohydrate; trimethylstannylazide / xylene / 115 - 120 °C

2.1: aq. NaOH / CH₂Cl₂; tetrahydrofuran / 0.25 h / 20 °C

2.2: tetrahydrofuran; CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; azidotrimethyltin; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1021/jm031100t