1-(1h-Indol-3-yl)cyclopropanecarbonitrile

Base Information

Chemical Name:1-(1h-Indol-3-yl)cyclopropanecarbonitrile
CAS No.:218772-64-6
Molecular Formula:C₁₂H₁₀N₂
Molecular Weight:182.225
Hs Code.:
DSSTox Substance ID:DTXSID101270900

Synonyms:1-(1h-indol-3-yl)cyclopropanecarbonitrile;218772-64-6;SCHEMBL998955;QURNDJMKRAFDHE-UHFFFAOYSA-N;DTXSID101270900;1-(1H-indole-3-yl)cyclopropanecarbonitrile;1-(1H-indol-3-yl)cyclopropane-1-carbonitrile;EN300-1838381

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(1h-Indol-3-yl)cyclopropanecarbonitrile

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:182.084398327
Heavy Atom Count:14
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC1(C#N)C2=CNC3=CC=CC=C32

Technology Process of 1-(1h-Indol-3-yl)cyclopropanecarbonitrile

There total 1 articles about 1-(1h-Indol-3-yl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-93-4
ethylene dibromide

: 218772-62-4
3-(cyanomethyl)-1H-indol-1-carboxylic acid tert-butyl ester

: 771-51-7
indole-3-acetonitrile

: 218772-64-6
1-(1H-indole-3-yl)cyclopropanecarbonitrile

Guidance literature:: ethylene dibromide; 3-(cyanomethyl)-1H-indol-1-carboxylic acid tert-butyl ester; With potassium hydroxide; In tert-butyl methyl ether; dimethyl sulfoxide; at 20 ℃; for 2h;

With hydrogenchloride; In water; Product distribution / selectivity;

Reference yield:

: 218772-64-6
1-(1H-indole-3-yl)cyclopropanecarbonitrile

: 1-(1,3-benzodioxol-5-yl)-N-(3,5-dimethylphenyl)-1,9-dihydrospiro[β-carboline-4,1’-cyclopropane]-2(3H)-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 80 °C

2: acetic acid / 70 - 100 °C

3: tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;