sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Base Information

Chemical Name:sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate
CAS No.:1187857-12-0
Molecular Formula:C₂₃H₂₅FNO₅*Na
Molecular Weight:437.443
Hs Code.:

Synonyms:sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

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Chemical Property of sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Chemical Property:

Purity/Quality:

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Technology Process of sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

There total 12 articles about sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187857-73-3
tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

: 1310-73-2
sodium hydroxide

: 1187857-12-0
sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate; With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 50 - 60 ℃; for 4h;

With hydrogenchloride; water;

sodium hydroxide; In water; isopropyl alcohol; at 40 - 60 ℃;

Reference yield:

: 1187856-50-3
2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid

: 1310-73-2
sodium hydroxide

: 1187857-12-0
sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: In isopropyl alcohol; at 25 - 30 ℃;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1187857-12-0
sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 105 °C

2.1: pyridine / 0 - 25 °C / Inert atmosphere

3.1: acetonitrile / 20 °C / Heating

4.1: dmap / acetonitrile / 18 h / 53 °C

5.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 7 h / 20 °C

6.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 4 h / 50 - 60 °C

6.3: 40 - 60 °C

With pyridine; dmap; tetrabutylammomium bromide; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; acetonitrile;