tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Base Information

Chemical Name:tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate
CAS No.:1187857-73-3
Molecular Formula:C₂₇H₃₄FNO₅
Molecular Weight:471.569
Hs Code.:

Synonyms:tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

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Chemical Property of tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Chemical Property:

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Technology Process of tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

There total 11 articles about tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

: 1187857-73-3
tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 20 ℃; for 7h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1187857-73-3
tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 105 °C

2: pyridine / 0 - 25 °C / Inert atmosphere

3: acetonitrile / 20 °C / Heating

4: dmap / acetonitrile / 18 h / 53 °C

5: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 7 h / 20 °C

With pyridine; dmap; tetrabutylammomium bromide; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; acetonitrile;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1187857-73-3
tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 105 °C

2: pyridine / 0 - 25 °C / Inert atmosphere

3: acetonitrile / 20 °C / Heating

4: dmap / acetonitrile / 18 h / 53 °C

5: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 7 h / 20 °C

With pyridine; dmap; tetrabutylammomium bromide; sodium hydroxide; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; toluene; acetonitrile;