2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid

Base Information

• Chemical Name: 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid
• CAS No.: 1187856-50-3
• Molecular Formula: C₂₃H₂₆FNO₅
• Molecular Weight: 415.462
• Mol file: 1187856-50-3.mol

Synonyms:2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid

Chemical Property of 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid

There total 16 articles about 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate (1187857-72-2) → 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (1187856-50-3)

Guidance literature:

ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate; With lithium bromide; In acetonitrile;

With triethylamine; In acetonitrile; at 70 ℃; for 2h;

With hydrogenchloride; water;

Reference yield:

tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate (1187857-73-3) → 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (1187856-50-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/acs.jmedchem.6b00871

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (1187856-50-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium t-butanolate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 105 °C

2.1: pyridine / 0 - 25 °C / Inert atmosphere

3.1: acetonitrile / 20 °C / Heating

4.1: dmap / acetonitrile / 18 h / 53 °C

5.1: rhodium(II) acetate / dichloromethane / 4 - 30 °C

6.1: lithium bromide / acetonitrile

6.2: 2 h / 70 °C

With pyridine; dmap; lithium bromide; sodium t-butanolate; rhodium(II) acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; toluene; acetonitrile;

upstream raw materials:

ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

trans-1,4-Cyclohexanedimethanol

tert-butyl 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl phenylcarbamate

Downstream raw materials:

potassium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

sodium 2-(((1r,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate