N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Base Information

• Chemical Name: N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide
• CAS No.: 1240518-30-2
• Molecular Formula: C₁₈H₂₀N₄O₂
• Molecular Weight: 324.382
• Mol file: 1240518-30-2.mol

Synonyms:N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Chemical Property of N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

There total 5 articles about N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine (1361330-32-6) + acetic acid (64-19-7,77671-22-8) → N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240518-30-2)

Guidance literature:

acetic acid; With HATU; In N,N-dimethyl-formamide; for 0.0833333h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0833333h;

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine; In N,N-dimethyl-formamide; for 3h;

Reference yield:

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240518-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2.1: HATU / N,N-dimethyl-formamide / 0.08 h

2.2: 0.08 h

2.3: 3 h

With lithium aluminium tetrahydride; HATU; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → N-[(3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240518-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4.1: HATU / N,N-dimethyl-formamide / 0.08 h

4.2: 0.08 h

4.3: 3 h

With lithium aluminium tetrahydride; hydrazine hydrate; HATU; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine

acetic acid

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

Downstream raw materials:

N-[(3-{[3-{[(2-fluorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide