Technology Process of (2Z)-2-benzylidene-5-fluoro-3,3-dimethyl-2,3-dihydrofuran
There total 4 articles about (2Z)-2-benzylidene-5-fluoro-3,3-dimethyl-2,3-dihydrofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydride;
In
tetrahydrofuran; mineral oil;
for 2h;
pH=7;
Inert atmosphere;
Reflux;
DOI:10.1055/s-0032-1317709
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / diethyl ether; hexane / -78 - 0 °C / Inert atmosphere
1.2: 12.25 h / -78 - 20 °C / pH 7 / Inert atmosphere
1.3: 1 h / 20 °C
2.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere; Molecular sieve
2.2: 5 h / 20 °C / pH 7 / Inert atmosphere
3.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / pH 7 / Inert atmosphere; Reflux
With
n-butyllithium; potassium hydride; diisopropylamine; Hexamethylphosphorous triamide;
In
tetrahydrofuran; diethyl ether; hexane; mineral oil;
DOI:10.1055/s-0032-1317709
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere; Molecular sieve
1.2: 5 h / 20 °C / pH 7 / Inert atmosphere
2.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / pH 7 / Inert atmosphere; Reflux
With
potassium hydride; Hexamethylphosphorous triamide;
In
tetrahydrofuran; mineral oil;
DOI:10.1055/s-0032-1317709
