4-amino-N-cyclopropylbenzenesulfonamide

Base Information

• Chemical Name: 4-amino-N-cyclopropylbenzenesulfonamide
• CAS No.: 177785-41-0
• Molecular Formula: C₉H₁₂N₂O₂S
• Molecular Weight: 212.272
• Hs Code.: 2935009090
• European Community (EC) Number: 835-364-7
• DSSTox Substance ID: DTXSID90360706
• Wikidata: Q72435504
• Mol file: 177785-41-0.mol

Synonyms:177785-41-0;4-amino-N-cyclopropylbenzenesulfonamide;N-Cyclopropyl 4-Aminophenylsulfonamide;4-amino-n-cyclopropylbenzene-1-sulfonamide;Benzenesulfonamide, 4-amino-N-cyclopropyl-;MFCD04035197;17785-41-0;SCHEMBL4071039;DTXSID90360706;N-Cyclopropyl4-Aminophenylsulfonamide;AKOS000200854;AC-2576;SB79523;AS-31573;SY002201;CS-0213087;FT-0763644;EN300-24500;J-514448;Z198745526

Chemical Property of 4-amino-N-cyclopropylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.22E-06mmHg at 25°C
• Boiling Point: 401°C at 760 mmHg
• Flash Point: 196.3°C
• PSA: 80.57000
• Density: 1.39g/cm³
• LogP: 2.76240
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 212.06194880
• Heavy Atom Count: 14
• Complexity: 284

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-cyclopropylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NS(=O)(=O)C2=CC=C(C=C2)N

Technology Process of 4-amino-N-cyclopropylbenzenesulfonamide

There total 4 articles about 4-amino-N-cyclopropylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.4%

→ 4-amino-N-cyclopropylbenzenesulfonamide (177785-41-0)

Guidance literature:

Reference yield:

C12H22NO2SSi2(1-)*Mg(2+)*Br(1-) + Cyclopropylamine (765-30-0) → 4-amino-N-cyclopropylbenzenesulfonamide (177785-41-0)

Guidance literature:

With sodium hypochlorite; water; In tetrahydrofuran; at 20 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201409283

Reference yield:

N-cyclopropyl-4-nitrobenzenesulfonamide (549476-61-1) → 4-amino-N-cyclopropylbenzenesulfonamide (177785-41-0)

Guidance literature:

With hydrogen;

DOI:10.1016/j.bmcl.2010.07.007

upstream raw materials:

N-cyclopropyl-4-nitrobenzenesulfonamide

Cyclopropylamine

4-Nitrobenzenesulfonyl chloride

Refernces

• 1、 Deeming, Alex S.,Russell, Claire J.,Willis, Michael C.. "Combining organometallic reagents, the sulfur dioxide surrogate DABSO, and amines: A One-pot preparation of sulfonamides, amenable to array synthesis". supporting information. p. 1168 - 1171. Retrieved 2015/01/30.
• 2、 -. "NOVEL ADENOSINE A3 RECEPTOR AGONISTS". Page/Page column 34. . Retrieved 2008/06/13.