[5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane
• CAS No.: 166523-69-9
• Molecular Formula: C₂₃H₃₇BrO₂Si
• Molecular Weight: 453.535

Synonyms:[5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane

Chemical Property of [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane

There total 3 articles about [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane (156170-20-6) → [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane (166523-69-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 18h; Ambient temperature;

DOI:10.1021/jm950747d

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane (166523-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / imidazole, DMAP / CH₂Cl₂ / 6 h / Ambient temperature

2: 88 percent / AIBN, n-Bu₃SnH / benzene / 18 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dichloromethane; benzene;

DOI:10.1021/jm950747d

Reference yield:

(3R)-Cyclocymopol monomethyl ether → [5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane (166523-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / imidazole, DMAP / CH₂Cl₂ / 6 h / Ambient temperature

2: 88 percent / AIBN, n-Bu₃SnH / benzene / 18 h / Ambient temperature

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dichloromethane; benzene;

DOI:10.1021/jm950747d

upstream raw materials:

[5-Bromo-2-((1R,3R)-3-bromo-2,2-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenoxy]-tert-butyl-dimethyl-silane

tert-butyldimethylsilyl chloride

Downstream raw materials:

(1R,3S)-3-[4-Bromo-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-benzyl]-4,4-dimethyl-2-methylene-cyclohexanol

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