2-Pyridinecarboxylic acid, 6-methyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 6-methyl-, 1,1-dimethylethyl ester
• CAS No.: 575433-87-3
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.24200
• Mol file: 575433-87-3.mol

Synonyms:tert-butyl 6-methylpicolinate;t-butyl 6-methylpyridine-2-carboxylate;6-methylpicolinic acid tert-butyl ester;

Chemical Property of 2-Pyridinecarboxylic acid, 6-methyl-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 39.19000
• LogP: 2.34530

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 6-methyl-, 1,1-dimethylethyl ester

There total 1 articles about 2-Pyridinecarboxylic acid, 6-methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

6-methyl-2-pyridinecarboxylic acid (934-60-1) + tert-Butyl 2,2,2-trichloroacetimidate (98946-18-0) → tert-butyl 6-(methyl)picolinate (575433-87-3)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

DOI:10.1039/c4dt00239c

Reference yield:

tert-butyl 6-(methyl)picolinate (575433-87-3) → N,N′-(2-nitrobenzenesulfonamide)-[N,N′-[6-(tert-butoxycarbonyl)pyridin-2-yl]methyl]-1,2-diaminoethane (1605289-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux

2: sodium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

With N-Bromosuccinimide; sodium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4dt00239c

Reference yield:

tert-butyl 6-(methyl)picolinate (575433-87-3) → N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1605289-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux

2: sodium carbonate / N,N-dimethyl-formamide / 48 h / 80 °C

With N-Bromosuccinimide; sodium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c4dt00239c

upstream raw materials:

6-methyl-2-pyridinecarboxylic acid

tert-Butyl 2,2,2-trichloroacetimidate

Downstream raw materials:

N,N′-(2-nitrobenzenesulfonamide)-N,N″-[[6-(methoxycarbonyl)-pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

N,N′-[[6-(methoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

N,N′-[[(6-carboxylato)pyridin-2-yl]methyl]-1-(p-benzylisothiocyanato)-1,2-diaminoethane

N,N′-[(tert-butoxycarbonyl)methyl]-N,N′-[[(6-tert-butoxycarbonyl)pyridin-2-yl]methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane