6-chloro-N2,N2-diethylpyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-chloro-N2,N2-diethylpyrimidine-2,4-diamine
• CAS No.: 3289-38-1
• Molecular Formula: C₈H₁₃ClN₄
• Molecular Weight: 200.671
• DSSTox Substance ID: DTXSID30541097
• Nikkaji Number: J1.224.007D
• Wikidata: Q72434362
• Mol file: 3289-38-1.mol

Synonyms:3289-38-1;6-chloro-N2,N2-diethylpyrimidine-2,4-diamine;4-AMINO-6-CHLORO-2-DIETHYLAMINOPYRIMIDINE;6-chloro-2-N,2-N-diethylpyrimidine-2,4-diamine;6-chloro-N~2~,N~2~-diethyl-2,4-pyrimidinediamine;6-Chloro-N2,N2-diethyl-2,4-pyrimidinediamine;sorbitanmonolaurate;SCHEMBL4251607;DTXSID30541097;MFCD09743981;AKOS006338840;SB57857;BS-37814;6-chloro-N2,N2-diethyl-pyrimidine-2,4-diamine;A821500;6-Chloro-N~2~,N~2~-diethylpyrimidine-2,4-diamine

Chemical Property of 6-chloro-N2,N2-diethylpyrimidine-2,4-diamine

Chemical Property:

• Vapor Pressure: 3.19E-05mmHg at 25°C
• Refractive Index: 1.6
• Boiling Point: 355.1 °C at 760 mmHg
• Flash Point: 168.6 °C
• PSA: 55.04000
• Density: 1.245 g/cm³
• LogP: 2.13960
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 200.0828741
• Heavy Atom Count: 13
• Complexity: 151

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-N~2~,N~2~-diethyl-2,4-pyrimidinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C1=NC(=CC(=N1)Cl)N

Technology Process of 6-chloro-N2,N2-diethylpyrimidine-2,4-diamine

There total 6 articles about 6-chloro-N2,N2-diethylpyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-amino-2,6-dichloropyrimidine (10132-07-7) + diethylamine (109-89-7) → 4-amino-6-chloro-2-diethylaminopyrimidine (3289-38-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 75 ℃;

DOI:10.1016/j.tetlet.2009.07.154

Reference yield: 30.0%

diethylamine (109-89-7) + 4-amino-6-chloro-2-methylsulphinylpyrimidine (66380-47-0) → 4-amino-6-chloro-2-diethylaminopyrimidine (3289-38-1)

Guidance literature:

In dimethyl sulfoxide; at 65 ℃; for 16h;

Reference yield: 5.0%

4-amino-6-chloro-2-methylsulphonylpyrimidine (74619-77-5) + diethylamine (109-89-7) → 4-amino-6-diethylamino-2-methylsulphonylpyrimidine (97229-14-6) + 4-amino-6-chloro-2-diethylaminopyrimidine (3289-38-1)

Guidance literature:

In dimethyl sulfoxide; at 65 ℃; for 16h;

upstream raw materials:

4-amino-6-chloro-2-methylsulphonylpyrimidine

diethylamine

4-amino-6-chloro-2-methylsulphinylpyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine