(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

Base Information

Chemical Name:(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime
CAS No.:1114924-91-2
Molecular Formula:C₂₀H₂₂ClN₇O₃
Molecular Weight:443.893
Hs Code.:

Synonyms:(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

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Chemical Property of (Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

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Technology Process of (Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

There total 4 articles about (Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1083086-53-6
(Z)?(1?methyl?1H?tetrazol?5?yl)(phenyl)methanone oxime

: 1114966-51-6
2-(t-butoxycarbonyl)amino-4-chloro-6-chloromethylpyridine

: 1114924-91-2
(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

Guidance literature:: (Z)?(1?methyl?1H?tetrazol?5?yl)(phenyl)methanone oxime; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; Ice cooling;

2-(t-butoxycarbonyl)amino-4-chloro-6-chloromethylpyridine; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h;

Reference yield:

: 1114966-47-0
ethyl 6-(t-butoxycarbonyl)amino-4-chloropicolinate

: 1114924-91-2
(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; ethanol / 17 h / 20 °C

2.1: pyridine; thionyl chloride / dichloromethane / 3.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Ice cooling

3.2: 3 h / 20 °C

With pyridine; sodium tetrahydroborate; thionyl chloride; ethanol; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 53389-01-8
diethyl 4-chloropyridine-2,6-dicarboxylate

: 1114924-91-2
(Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium hydroxide / ethanol / 20 - 55 °C

1.2: pH 2.5

2.1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 20 - 60 °C

2.2: 18 h / 60 °C

3.1: sodium tetrahydroborate; ethanol / 17 h / 20 °C

4.1: pyridine; thionyl chloride / dichloromethane / 3.5 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Ice cooling

5.2: 3 h / 20 °C

With pyridine; sodium tetrahydroborate; thionyl chloride; ethanol; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;