53389-01-8

Basic information

• Product Name: DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE
• Synonyms: DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE;DIETHYL 4-CHLOROPYRIDINE-2,6-DICARBOXYLATE;4-Chloro-2,6-pyridinedicarboxylic acid diethyl ester;Diethyl 4-Chloropyridine- 2,6-pyridinedicarboxylate;4-chloropyridine-2,6-dicarboxylate;4-Chloro-2,6-(diethoxycarbonyl)pyridine;4-chloropyidine-2,6-dicarboxylate;Ethyl 4-chloropyidine-2,6-dicarboxylate
• CAS NO: 53389-01-8
• Molecular Formula: C₁₁H₁₂ClNO₄
• Molecular Weight: 257.67
• Product Categories: Pyridines;Esters
• Mol File: 53389-01-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 91-93°
• Boiling Point: 378.5 °C at 760 mmHg
• Flash Point: 182.7 °C
• Appearance: /
• Density: 1.266
• Vapor Pressure: 6.26E-06mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.14±0.10(Predicted)
• CAS DataBase Reference: DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE(53389-01-8)
• EPA Substance Registry System: DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE(53389-01-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 53389-01-8(Hazardous Substances Data)

Usage

Uses

Diethyl 4-Chloropyridine-2,6-dicarboxylate is a chemical reagent used in the synthesis of luminescent lanthanide complexes. Also used in the production of metal chelating inhibitors against fructose 1,6-bisphosphate (FBP) aldolase in the treatment of infectious bacteria and fungi.

InChI:InChI=1/C11H12ClNO4/c1-3-16-10(14)8-5-7(12)6-9(13-8)11(15)17-4-2/h5-6H,3-4H2,1-2H3

Upstream product

• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 64-17-5 ethanol 
• 138-60-3 chelidamic acid 
• 499-51-4 Chelidamic acid 

Downstream Products

• 18986-18-0 4-ethoxy-2,6-pyridinedicarboxylate d'ethyle 
• 112776-86-0 diethyl 4-(phenylethynyl)-2,6-pyridinedicarboxylate 
• 1038409-81-2 C₁₇H₁₇ClN₂O₅S 
• 197712-58-6 4-Methyl-pyridine-2,6-dicarboxylic acid diethyl ester 
• 1114924-91-2 (Z)-(1-methyl-1H-tetrazol-5-yl)phenylmethanone-O-[2-(t-butoxycarbonyl)amino-4-chloropyridin-6-ylmethyl]-oxime 
• 1114966-47-0 ethyl 6-(t-butoxycarbonyl)amino-4-chloropicolinate 

Relevant articles and documents

1O2 Generating Luminescent Lanthanide Complexes with 1,8-Naphthalimide-Based Sensitizers

Lanthanide ion (LnIII) complexes with two new 1,8-naphthalimide-based ligands, Nap-dpe and Nap-cbx, were isolated, and their photophysical properties were explored. Upon excitation at 335 nm, Nap-dpe and Nap-cbx sensitize visible and near-infra

BODIPY-based hydroxypyridyl derivative as a highly Ni2+-selective fluorescent chemosensor

A novel fluorescent chemosensor based on BODIPY-NO2 was synthesized and characterized by NMR, MALDI-MS, UV-Vis and fluorescence spectrum. Also, the single-crystal structure of BODIPY-NO2 was determined by X-ray crystallography. The chemosensor shows selective “turn-off” fluorescence response to Ni2+ ion over various other competing metal ions such as Li+, K+, Ca2+, Mg2+, Hg2+, Cu2+, Zn2+, Cd2+ and Mn2+ in CH3CN solution. The BODIPY-NO2 showed a visible absorption band at 502 nm with a shoulder at the shorter wavelength side. The fluorescence emission band was observed at 543 nm of the sensor in the presence of Ni2+ ion with high quantum yield (Φ: 0.39). The square planar [Ni(BODIPY-NO2)(CH3CN)] metal center acts as an efficient quencher for the excited-state based on electron-transfer processes. The BODIPY-NO2 to Ni2+ sensitive nature was determined from the limit of detection 1.7 × 10?7 M in fluorescence emission. The chemosensor BODIPY-NO2 binds to Ni2+ in a 1:1 molar ratio calculated by the job's plot and the binding constant is determined to be 3.1 × 105 M?1. The fluorescence quenching occurred in an acid condition, using the titration experiment with pH 1.0–4.0.

An efficient triazole-pyridine-bistetrazolate platform for highly luminescent lanthanide complexes

Two new triazole-pyridine-bistetrazolate ligands were synthesized via a versatile procedure that allows for further derivatization; their corresponding homoleptic tris-ligand nona-coordinated lanthanide complexes are highly luminescent in the solid state and in a PVA polymeric matrix with measured values for the luminescence quantum yield of 70(7) and 98(9)% for Eu III and TbIII, respectively. This journal is the Partner Organisations 2014.