methyl N-benzyl-piperidin-4-yl-cyanoacetate

Base Information

• Chemical Name: methyl N-benzyl-piperidin-4-yl-cyanoacetate
• CAS No.: 743417-80-3
• Molecular Formula: C₁₆H₂₀N₂O₂
• Molecular Weight: 272.347
• Mol file: 743417-80-3.mol

Synonyms:methyl N-benzyl-piperidin-4-yl-cyanoacetate

Chemical Property of methyl N-benzyl-piperidin-4-yl-cyanoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl N-benzyl-piperidin-4-yl-cyanoacetate

There total 5 articles about methyl N-benzyl-piperidin-4-yl-cyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

methanol (67-56-1) + 2-(1-benzylpiperidin-4-ylidene)malononitrile (616897-44-0) → methyl N-benzyl-piperidin-4-yl-cyanoacetate (743417-80-3)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate;

DOI:10.1016/j.bmcl.2004.07.005

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → methyl N-benzyl-piperidin-4-yl-cyanoacetate (743417-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.3 percent / CH₂Cl₂ / 20 °C

2: 85.5 percent / NaBH₄; HCl

With hydrogenchloride; sodium tetrahydroborate; In dichloromethane;

DOI:10.1016/j.bmcl.2004.07.005

Reference yield:

N-benzyl-piperidin-4-yl-malonitrile (744195-35-5) → methyl N-benzyl-piperidin-4-yl-cyanoacetate (743417-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / CH₂Cl₂ / 5 h / Heating

2: HCl gas

With hydrogenchloride; sodium tetrahydroborate; In dichloromethane;

DOI:10.1081/SCC-120021515

upstream raw materials:

methanol

2-(1-benzylpiperidin-4-ylidene)malononitrile

1-phenylmethyl-4-piperidone

N-benzyl-piperidin-4-yl-malonitrile

Downstream raw materials:

1-(phenylmethyl)-4-piperidineacetonitrile