Technology Process of 1-methyl-3-phenyl-5,6-dihydropyrazin-2(1H)-one
There total 4 articles about 1-methyl-3-phenyl-5,6-dihydropyrazin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-phenyl-5,6-dihydropyrazin-2(1H)-one;
With
sodium hydride;
In
1,2-dimethoxyethane; mineral oil;
at -5 - 20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
methyl iodide;
In
1,2-dimethoxyethane; mineral oil;
at 20 ℃;
for 16h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/adsc.201700175
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium sulfate / toluene / 2 h / Inert atmosphere; Reflux; Schlenk technique
2.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 1 h / -5 - 20 °C / Inert atmosphere; Schlenk technique
2.2: 16 h / 20 °C / Inert atmosphere; Schlenk technique
With
sodium hydride; sodium sulfate;
In
1,2-dimethoxyethane; toluene; mineral oil;
DOI:10.1002/adsc.201700175
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: perchloric acid / pyridine; acetonitrile; water / 0.5 h / Inert atmosphere; Molecular sieve; Schlenk technique
2.1: sodium sulfate / toluene / 2 h / Inert atmosphere; Reflux; Schlenk technique
3.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 1 h / -5 - 20 °C / Inert atmosphere; Schlenk technique
3.2: 16 h / 20 °C / Inert atmosphere; Schlenk technique
With
perchloric acid; sodium hydride; sodium sulfate;
In
pyridine; 1,2-dimethoxyethane; water; toluene; acetonitrile; mineral oil;
DOI:10.1002/adsc.201700175
