6956-56-5Relevant articles and documents
The Synthesis of α-Keto Acetals from Terminal Alkynes and Alcohols via Synergistic Interaction of Organoselenium Catalysis and Electrochemical Oxidation
Ding, Ding,Xu, Liang,Wei, Yu
, p. 4912 - 4917 (2022/03/02)
Herein, an unprecedented electrochemical approach for the synthesis of α-keto acetals has been established from readily available terminal alkynes and alcohols. By merging the electrochemical and organoselenium-catalyzed processes, the desired products are obtained at room temperature in the absence of basic or metallic additives, with carbonyl and acetal motifs incorporated simultaneously across the triple bonds in a single operation.
Rapid, One-Step Synthesis of α-Ketoacetals via Electrophilic Etherification
Paris, Timothy J.,Schwartz, Chris,Sundall, Eric,Willand-Charnley, Rachel
, p. 14797 - 14811 (2021/10/20)
Herein, we report a rapid, one-step synthesis of α-ketoacetals via electrophilic etherification of α-alkoxy enolates and monoperoxyacetals. Methyl, primary, and secondary α-ketoacetals were obtained in 44-63% yields from tetrahydropyranyl substrates; usin
Green synthesis of 2, 2-dialkoxy acetophenone derivative
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Paragraph 0017, (2020/04/17)
The invention provides green synthesis of a 2, 2-dialkoxy acetophenone derivative (1), and the structure of the 2, 2-dialkoxy acetophenone derivative (1) is shown as follows, wherein R is alkyl, and R1 is one or more of alkyl, halogen, alkoxy, N, N-dialkylamine or benzoring. According to the method, the 2, 2-dichloroacetophenone derivative, alcohol and alkali are taken as raw materials and are subject to heating and stirring to obtain a target product 2, filtering is performed after the reaction is completed, filtrate is concentrated, and a high-yield and high-purity product can be obtained. The method has the advantages of simple operation, few byproducts, and no generation of any toxic or environmentally harmful substances in the reaction. A new synthesis method is provided for the target product 1.
