(2S)-2-aminobutyramide

Base Information

• Chemical Name: (2S)-2-aminobutyramide
• CAS No.: 7324-11-0
• Molecular Formula: C₄H₁₀N₂O
• Molecular Weight: 102.136
• European Community (EC) Number: 615-935-5
• UNII: 1LY48BJG06
• DSSTox Substance ID: DTXSID40426720
• Nikkaji Number: J508.306K
• Wikidata: Q76393684
• Mol file: 7324-11-0.mol

Synonyms:(2S)-2-aminobutyramide;7324-11-0;(s)-2-aminobutanamide;143164-46-9;(2S)-2-aminobutanamide;Butanamide, 2-amino-, (2S)-;2-Aminobutanamide, (S)-;1LY48BJG06;UNII-1LY48BJG06;Levetiracetam impurity G [EP];L-alpha-Aminobutyric acid amide;(S)-2-Aminobutyramid;(s)-2-aminobutyramide;SCHEMBL428684;DTXSID40426720;HNNJFUDLLWOVKZ-VKHMYHEASA-N;MFCD00136552;(2S)-2-aminobutyramide, AldrichCPR;AKOS006274147;AS-49437;L-2-Aminobutanamide;(S)-2-Aminobutanamide;A9464;LEVETIRACETAM IMPURITY G [EP IMPURITY];EN300-862086;I10243;A808032;XKV

Chemical Property of (2S)-2-aminobutyramide

Chemical Property:

• Boiling Point: 245.7 °C at 760 mmHg
• PKA: 16.07±0.50(Predicted)
• Flash Point: 102.4 °C
• PSA: 69.11000
• Density: 1.027 g/cm³
• LogP: 0.60960
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 102.079312947
• Heavy Atom Count: 7
• Complexity: 72.1

Purity/Quality:

98%, ^*data from raw suppliers

(S)-2-Aminobutanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(=O)N)N
• Isomeric SMILES: CC[C@@H](C(=O)N)N

Technology Process of (2S)-2-aminobutyramide

There total 11 articles about (2S)-2-aminobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

(S)-2-amino-butanamide hydrochloride (53726-14-0,7682-20-4,141978-61-2) → (S)-2-amino-butanamide (7324-11-0,53726-14-0,104652-77-9,143164-46-9)

Guidance literature:

With ammonia; In isopropyl alcohol; at 0 ℃; for 4h; Industrial scale;

Reference yield: 91.0%

→ (S)-2-amino-butanamide (7324-11-0,53726-14-0,104652-77-9,143164-46-9)

Guidance literature:

Reference yield: 87.71%

2-aminobutyronitrile (40651-89-6) → (S)-2-amino-butanamide (7324-11-0,53726-14-0,104652-77-9,143164-46-9)

Guidance literature:

With tetraethylammonium bromide; water; sodium hydroxide; In acetone; at 0 - 10 ℃; for 37h; Reagent/catalyst;

upstream raw materials:

(S)-2-amino-butanamide hydrochloride

(S)-2-aminobutyric acid methyl ester hydrochloride

S-(+)-2-amino-n-butyric acid hydrochloride

2-aminobutanoic acid

Downstream raw materials:

brivaracetam

((2S)-2-[(4S)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl]butanamide)

(S)-2-(4-chlorobutyramido)butanamide

levetiracetam

Refernces

• 1、 Aguiar, Renata M.,Le?o, Raquel A. C.,Mata, Alejandro,Cantillo, David,Kappe, C. Oliver,Miranda, Leandro S. M.,De Souza, Rodrigo O. M. A.. "Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients". supporting information. p. 1552 - 1557. Retrieved 2019/02/14.
• 2、 -. "Processing technique of L-2-amino butyramide hydrochloride". Paragraph 0017; 0018. . Retrieved 2017/02/02.