Ethyl 4-hydroxybutanoate

Base Information

• Chemical Name: Ethyl 4-hydroxybutanoate
• CAS No.: 999-10-0
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 2918199090
• Mol file: 999-10-0.mol

Synonyms:Butyricacid, 4-hydroxy-, ethyl ester (6CI,7CI,8CI);Ethyl 4-hydroxybutanoate;Ethyl4-hydroxybutyrate;Ethyl g-hydroxybutyrate;NSC 617295;

Chemical Property of Ethyl 4-hydroxybutanoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 204.8 °C at 760 mmHg
• PKA: 14.88±0.10(Predicted)
• Flash Point: 81.4 °C
• PSA: 46.53000
• Density: 1.027 g/cm³
• LogP: 0.32200
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Sparingly), Methaol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl4-hydroxybutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-hydroxybutanoate

There total 22 articles about Ethyl 4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-butanolide (96-48-0) + ethanol (64-17-5) → ethyl 4-hydroxybutanoate (999-10-0)

Guidance literature:

With amberlyst-15; for 20h;

DOI:10.1080/00397919408010590

Reference yield: 86.0%

4-isopropoxycarbonyloxy-butyric acid ethyl ester → ethyl 4-hydroxybutanoate (999-10-0)

Guidance literature:

With aluminium trichloride; In nitromethane; at 25 ℃; for 3h;

DOI:10.1055/s-2001-17466

Reference yield: 68.0%

Ethyl 4-bromobutyrate (2969-81-5) → ethyl 4-hydroxybutanoate (999-10-0) + ethyl cyclopropylcarboxylate (4606-07-9)

Guidance literature:

With oxygen; tetraethylammonium perchlorate; In N,N-dimethyl-formamide; at 20 ℃; electroreduction at -1.1 V;

upstream raw materials:

4-butanolide

triethyloxonium fluoroborate

3,3-Bis-ethylsulfanylcarbonyl-propionic acid ethyl ester

ethanol

Downstream raw materials:

ethyl 4-oxobutanoate

tert-butyl 2-(4-ethoxy-4-oxobutanoyl)-3-(2-nitrophenyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

N-benzyl-4-hydroxybutanamide

Refernces

• 1、 Huang, Zhiwei,Barnett, Kevin J.,Chada, Joseph P.,Brentzel, Zachary J.,Xu, Zhuoran,Dumesic, James A.,Huber, George W.. "Hydrogenation of γ-Butyrolactone to 1,4-Butanediol over CuCo/TiO2 Bimetallic Catalysts". . p. 8429 - 8440. Retrieved 2017/12/08.
• 2、 Van Doorslaer, Charlie,Peeters, Annelies,Mertens, Pascal,Vinckier, Chris,Binnemans, Koen,De Vos, Dirk. "Oxidation of cyclic acetals by ozone in ionic liquid media". experimental part. p. 6439 - 6441. Retrieved 2010/03/04.