tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate
CAS No.:1360598-39-5
Molecular Formula:C₂₉H₃₈N₄O₆S
Molecular Weight:570.71
Hs Code.:

Synonyms:tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

There total 10 articles about tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1360598-37-3
tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

: 74-88-4
methyl iodide

: 1360598-39-5
tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; at 40 ℃; for 12h;

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 1360598-39-5
tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate; cesium fluoride / N,N-dimethyl-formamide / 20 - 60 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C

3.1: tetrahydrofuran / 18 h / Reflux

3.2: 24 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4.2: 13 h / -5 - 20 °C

5.1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

6.1: triethylamine / dichloromethane / 3 h

7.1: potassium hydroxide; water / methanol / 8 h / 50 °C

8.1: diphenyl phosphoryl azide; triethylamine / 20 h / Inert atmosphere

9.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

9.2: 12 h / 40 °C

With diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; butan-1-ol;

Reference yield:

: 1360598-30-6
ethyl 3-amino-1-(phenylsulfonyl)indolizine-2-carboxylate

: 1360598-39-5
tert-butyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

2.1: triethylamine / dichloromethane / 3 h

3.1: potassium hydroxide; water / methanol / 8 h / 50 °C

4.1: diphenyl phosphoryl azide; triethylamine / 20 h / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

5.2: 12 h / 40 °C

With diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil; butan-1-ol;