tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate
CAS No.:1360598-37-3
Molecular Formula:C₂₈H₃₆N₄O₆S
Molecular Weight:556.683
Hs Code.:

Synonyms:tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

There total 9 articles about tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1360598-35-1
3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-(phenylsulfonyl)indolizine-2-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1360598-37-3
tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 20h; Inert atmosphere;

Reference yield:

: 4377-33-7
2-chloromethylpyridine

: 1360598-37-3
tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate; cesium fluoride / N,N-dimethyl-formamide / 20 - 60 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / -5 - 0 °C

3.1: tetrahydrofuran / 18 h / Reflux

3.2: 24 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4.2: 13 h / -5 - 20 °C

5.1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

6.1: triethylamine / dichloromethane / 3 h

7.1: potassium hydroxide; water / methanol / 8 h / 50 °C

8.1: diphenyl phosphoryl azide; triethylamine / 20 h / Inert atmosphere

With diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; cesium fluoride; potassium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1360598-30-6
ethyl 3-amino-1-(phenylsulfonyl)indolizine-2-carboxylate

: 1360598-37-3
tert-butyl 4-(2-(tert-butoxycarbonylamino)-1-(phenylsulfonyl)indolizin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / butan-1-ol / 72 h / Reflux

2: triethylamine / dichloromethane / 3 h

3: potassium hydroxide; water / methanol / 8 h / 50 °C

4: diphenyl phosphoryl azide; triethylamine / 20 h / Inert atmosphere

With diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; In methanol; dichloromethane; butan-1-ol;