Sucrosofate sodium

Base Information

• Chemical Name: Sucrosofate sodium
• CAS No.: 74135-10-7
• Molecular Formula: C₁₂H₁₄O₃₅S₈*8Na
• Molecular Weight: 1158.67
• Hs Code.: 28331900
• UNII: S391KJ684Q
• Nikkaji Number: J1.922.033H
• Wikidata: Q27288530
• Mol file: 74135-10-7.mol

Synonyms:74135-10-7;Sucrosofate sodium;Sucrose octasulfate sodium salt;Sucroseoctasulfatesodiumsalt;Sodium Sucrose Octasulfate;Sodium sucrose octasulfate [INCI];UNII-S391KJ684Q;S391KJ684Q;octasodium;[(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl] sulfate;Sucrose octasulfate, sodium salt;alpha-D-Glucopyranoside, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl, 2,3,4,6-tetrakis(hydrogen sulfate), sodium salt (1:8);C12H14Na8O35S8;a-D-Glucopyranoside, 1,3,4,6-tetra-O-sulfo-b-D-fructofuranosyl,tetrakis(hydrogen sulfate), octasodium salt;Sucrose octasulphate sodium salt;EX-A5420B;AKOS032947940;AS-83612;sucrose-octa-O-sulphonic acid sodium salt;D97625;A904774;Q27288530;.ALPHA.-D-GLUCOPYRANOSIDE, 1,3,4,6-TETRA-O-SULFO-.BETA.-D-FRUCTOFURANOSYL, 2,3,4,6-TETRAKIS(HYDROGEN SULFATE), SODIUM SALT (1:8);1-O,3-O,4-O,6-O-Tetrakis(sodiosulfo)-beta-D-fructofuranosyl 2-O,3-O,4-O,6-O-tetrakis(sodiosulfo)-alpha-D-glucopyranoside;a-D-Glucopyranoside,1,3,4,6-tetra-O-sulfo-b-D-fructofuranosyl,tetrakis(hydrogen sulfate),sodium salt(9ci);Octasodium 1,3,4,6-tetra-O-sulfonato-beta-D-fructofuranosyl 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranoside

Chemical Property of Sucrosofate sodium

Chemical Property:

• Appearance/Colour: White Powder
• Melting Point: 159-164°C
• PSA: 626.17000
• Density: 2.097 at 20℃
• LogP: -0.87320
• Storage Temp.: -20°C Freezer
• Solubility.: Water (Sparingly, Sonicated)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 35
• Rotatable Bond Count: 13
• Exact Mass: 1157.6262858
• Heavy Atom Count: 63
• Complexity: 2130

Purity/Quality:

99% ^*data from raw suppliers

Sucrose Octasulfate, Sodium Salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])COS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
• Uses: Used as a reference standard for the drug Sucralfate Sodium sucrose octasulfate is a chemical compound, and it has been used clinically for the prevention of gastrointestinal ulcers and was found to have cytoprotective effects. The sodium compounds are contents of various cosmetics for skin care and it was also evaluated in patients with cancer for the prevention and management of radiodermatitis. Used as a reference standard for the drug Sucralfate.

Technology Process of Sucrosofate sodium

There total 4 articles about Sucrosofate sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Sucrose (57-50-1) → sucrose octasulphate sodium salt (74135-10-7,127930-09-0)

Guidance literature:

With triethylamine sulfurtrioxide; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

DOI:10.1023/A:1016161001013

Reference yield:

ammonium salt of sucrose octasulfate (74135-13-0,131587-92-3) → sucrose octasulphate sodium salt (74135-10-7,127930-09-0)

Guidance literature:

With Amberlite IR 120PLUS cation exchange resin; In water; Activated charcoal;

Reference yield:

barium salt of sucrose octasulfate (74135-09-4) → sucrose octasulphate sodium salt (74135-10-7,127930-09-0)

Guidance literature:

With Amberlite IR-120 (Na+); In water;

DOI:10.1248/cpb.28.638

upstream raw materials:

barium salt of sucrose octasulfate

Sucrose

ammonium salt of sucrose octasulfate

Refernces

• 1、 Hiebert, Linda M,Wice, Sandra M,Ping, Tidly,Hileman, Ronald E,Polat, Tfilay,Linhardt, Robert J. "Tissue distribution of [14C]sucrose octasulfate following oral administration to rats.". . p. 838 - 844. Retrieved 2007/10/03.
• 2、 Ochi,Watanabe,Okui,Shindo. "Crystalline salts of sucrose octasulfate". . p. 638 - 641. Retrieved 2007/10/02.