(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Base Information

Chemical Name:(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate
CAS No.:164359-89-1
Molecular Formula:C₁₅H₂₂F₂O₃
Molecular Weight:288.335
Hs Code.:

Synonyms:(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Suppliers and Price of (+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

There total 5 articles about (+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 164359-88-0
(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

: 164359-89-1
(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Guidance literature:: In pyridine; for 13h; Ambient temperature;
DOI:10.1016/0031-9422(94)00693-N

Reference yield:

: 90611-50-0
(+/-)-2-formyl-2,6-dimethyl-1-cyclohexanone

: 164359-89-1
(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 4 h / Ambient temperature

2: 77 percent / BuLi / hexane; tetrahydrofuran / 2 h / -25 - -10 °C

3: 97 percent / pyridinium p-toluenesulphonate / ethanol / 5 h / 55 °C

4: 85 percent / pyridine / 13 h / Ambient temperature

With n-butyllithium; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; pyridine; ethanol; hexane; dichloromethane;
DOI:10.1016/0031-9422(94)00693-N

Reference yield:

: 13756-98-4
(+/-)-2-hydroxymethyl-2,6-dimethyl-1-cyclohexanone

: 164359-89-1
(+/-)-3-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)-1-methyl-2-propynyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

2: 45 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 4 h / Ambient temperature

3: 77 percent / BuLi / hexane; tetrahydrofuran / 2 h / -25 - -10 °C

4: 97 percent / pyridinium p-toluenesulphonate / ethanol / 5 h / 55 °C

5: 85 percent / pyridine / 13 h / Ambient temperature

With n-butyllithium; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; pyridinium chlorochromate; In tetrahydrofuran; pyridine; ethanol; hexane; dichloromethane;
DOI:10.1016/0031-9422(94)00693-N