(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Base Information

Chemical Name:(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol
CAS No.:164359-88-0
Molecular Formula:C₁₃H₂₀F₂O₂
Molecular Weight:246.297
Hs Code.:

Synonyms:(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Suppliers and Price of (+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Chemical Property:

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Technology Process of (+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

There total 4 articles about (+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 164359-87-9
(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol-tetrahydropyranyl ether

: 164359-88-0
(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 55 ℃; for 5h;
DOI:10.1016/0031-9422(94)00693-N

Reference yield:

: 90611-50-0
(+/-)-2-formyl-2,6-dimethyl-1-cyclohexanone

: 164359-88-0
(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 4 h / Ambient temperature

2: 77 percent / BuLi / hexane; tetrahydrofuran / 2 h / -25 - -10 °C

3: 97 percent / pyridinium p-toluenesulphonate / ethanol / 5 h / 55 °C

With n-butyllithium; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1016/0031-9422(94)00693-N

Reference yield:

: 13756-98-4
(+/-)-2-hydroxymethyl-2,6-dimethyl-1-cyclohexanone

: 164359-88-0
(+/-)-4-(1'-hydroxy-2'-difluoromethyl-2',6'-dimethylcyclohexyl)but-3-yn-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h / Ambient temperature

2: 45 percent / diethylaminosulphur trifluoride / CH₂Cl₂ / 4 h / Ambient temperature

3: 77 percent / BuLi / hexane; tetrahydrofuran / 2 h / -25 - -10 °C

4: 97 percent / pyridinium p-toluenesulphonate / ethanol / 5 h / 55 °C

With n-butyllithium; diethylamino-sulfur trifluoride; pyridinium p-toluenesulfonate; pyridinium chlorochromate; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1016/0031-9422(94)00693-N