(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Base Information

Chemical Name:(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate
CAS No.:1415694-88-0
Molecular Formula:C₂HF₃O₂*C₂₀H₁₉N₅O₃
Molecular Weight:491.427
Hs Code.:

Synonyms:(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

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Chemical Property of (3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

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Technology Process of (3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

There total 12 articles about (3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415695-13-4
Methyl 3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzoate

: 76-05-1
trifluoroacetic acid

: 1415694-88-0
(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: Methyl 3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h;

With water; In tetrahydrofuran; Cooling with ice;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 20511-12-0
2-amino-5-iodopyridine

: 1415694-88-0
(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / acetonitrile / 72 h / 20 °C

2.1: isopropyl alcohol / Inert atmosphere; Reflux

2.2: 50 °C

3.1: trifluoroacetic anhydride / tetrahydrofuran / 0 - 20 °C

3.2: pH 8

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 24.25 h / 20 °C / Inert atmosphere; Reflux

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24.16 h / 20 - 96 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C

6.2: Cooling with ice

With N-Bromosuccinimide; lithium aluminium tetrahydride; sodium carbonate; caesium carbonate; trifluoroacetic anhydride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 211308-81-5
5-chloro-3-iodo-2-aminopyridine

: 1415694-88-0
(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)phenyl)methanol 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 5 h / 20 - 100 °C

1.2: 16 h / 50 - 60 °C

2.1: trifluoroacetic anhydride / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 44 h / 95 °C / Reflux

4.1: sodium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / Reflux; Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C

5.2: Cooling with ice

With lithium aluminium tetrahydride; sodium carbonate; caesium carbonate; trifluoroacetic anhydride; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; xylene;