C₆₁H₈₄N₁₂O₁₃S₃

Base Information

Chemical Name:C₆₁H₈₄N₁₂O₁₃S₃
CAS No.:1453168-04-1
Molecular Formula:C₆₁H₈₄N₁₂O₁₃S₃
Molecular Weight:1289.61
Hs Code.:

C<sub>61</sub>H<sub>84</sub>N<sub>12</sub>O<sub>13</sub>S<sub>3</sub>

Synonyms:C₆₁H₈₄N₁₂O₁₃S₃

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Chemical Property of C₆₁H₈₄N₁₂O₁₃S₃

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Technology Process of C₆₁H₈₄N₁₂O₁₃S₃

There total 13 articles about C₆₁H₈₄N₁₂O₁₃S₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1453168-03-0
C₄₀H₄₉N₉O₆S₂

: 365441-71-0
4,7,10,13-tetraoxa-16-azaheneicosanoic acid 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-2,5-dioxo-1-pyrrolidinyl ester

: 1453168-04-1
C₆₁H₈₄N₁₂O₁₃S₃

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ol401749p

Reference yield:

: 18942-49-9
Boc-D-Phe-OH

: 1453168-04-1
C₆₁H₈₄N₁₂O₁₃S₃

Guidance literature:: Multi-step reaction with 13 steps

1.1: methanol; benzene; hexane / 0.5 h / Inert atmosphere

2.1: ammonium hydroxide / methanol

3.1: Lawessons reagent / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

4.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

4.3: 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic acid; methoxybenzene / dichloromethane

6.1: N-ethyl-N,N-diisopropylamine; HATU; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid; methoxybenzene / dichloromethane

8.1: N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: lithium hydroxide; dihydrogen peroxide / ethanol

10.1: trifluoroacetic acid; methoxybenzene / dichloromethane

11.1: N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

12.1: hydrogen bromide; acetic acid / 1 h

13.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; hydrogen bromide; dihydrogen peroxide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; methoxybenzene; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; benzene;
DOI:10.1021/ol401749p

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1453168-04-1
C₆₁H₈₄N₁₂O₁₃S₃

Guidance literature:: Multi-step reaction with 12 steps

1.1: ammonium hydroxide / methanol

2.1: Lawessons reagent / 1,2-dimethoxyethane / 20 °C / Inert atmosphere

3.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

3.3: 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; methoxybenzene / dichloromethane

5.1: N-ethyl-N,N-diisopropylamine; HATU; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid; methoxybenzene / dichloromethane

7.1: N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: lithium hydroxide; dihydrogen peroxide / ethanol

9.1: trifluoroacetic acid; methoxybenzene / dichloromethane

10.1: N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

11.1: hydrogen bromide; acetic acid / 1 h

12.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; hydrogen bromide; dihydrogen peroxide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; methoxybenzene; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1021/ol401749p