1-(2-Nitrophenyl)-1,2-ethanediol

Base Information

• Chemical Name: 1-(2-Nitrophenyl)-1,2-ethanediol
• CAS No.: 51673-59-7
• Molecular Formula: C8H9NO4
• Molecular Weight: 183.164
• Hs Code.: 2906299090
• Mol file: 51673-59-7.mol

Synonyms:(o-Nitrophenyl)ethyleneglycol;1-(2-Nitrophenyl)ethane-1,2-diol;2-(o-Nitrophenyl)-1,2-ethanediol;

Chemical Property of 1-(2-Nitrophenyl)-1,2-ethanediol

Chemical Property:

• Vapor Pressure: 4.51E-07mmHg at 25°C
• Melting Point: 96-98 °C(lit.)
• Refractive Index: 1.616
• Boiling Point: 398.7 °C at 760 mmHg
• PKA: 13.02±0.20(Predicted)
• Flash Point: 180.5 °C
• PSA: 86.28000
• Density: 1.41g/cm³
• LogP: 1.14370

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Nitrophenyl)-1,2-ethanediol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Nitrophenyl)-1,2-ethanediol

There total 8 articles about 1-(2-Nitrophenyl)-1,2-ethanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-nitrostyrene (579-71-5) → 1-(2-nitrophenyl)ethane-1,2-diol (51673-59-7)

Guidance literature:

With dihydrogen peroxide; ethyl acetate; lipase [PSLG₆]; In water; at 60 ℃; for 0.116667h; microwave irradiation;

DOI:10.1016/j.tetlet.2007.07.087

Reference yield: 69.4%

p-Nitrophenyloxirane (6388-74-5,38201-14-8,71884-55-4) → 1-(2-nitrophenyl)ethane-1,2-diol (51673-59-7)

Guidance literature:

With potassium carbonate; In aqueous 1,4-dioxane;

Reference yield:

2-acetylnitrobenzene (577-59-3) → 1-(2-nitrophenyl)ethane-1,2-diol (51673-59-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / bromine / dioxane / 2 h

2: 88 percent / sodium borohydride / dioxane; H₂O / 1.) 2 h at 5 deg C; 2.) 30 min room temperature

3: 78 percent / 10 percent aq potassium carbonate / dioxane / 17 h / Heating; in the dark

With sodium tetrahydroborate; bromine; potassium carbonate; In 1,4-dioxane; water;

upstream raw materials:

p-Nitrophenyloxirane

2-nitrostyrene

ethyl acetate

2-acetylnitrobenzene

Downstream raw materials:

di(tert-butyl) 4-(2-nitrophenyl)-3,6-dioxaoctanedioate

Acetic acid (3S,8S,10R,13S,14S,17S)-10,13-dimethyl-17-[2-methyl-4-(2-nitro-phenyl)-[1,3]dioxolan-2-yl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

C₂₉H₃₇NO₆

2-(2-Nitro-phenyl)-1,4-dioxa-spiro[4.5]decane