(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

Base Information

Chemical Name:(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal
CAS No.:215317-79-6
Molecular Formula:C₂₀H₃₀O₃S₂
Molecular Weight:382.588
Hs Code.:

Synonyms:(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

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Chemical Property of (3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

Chemical Property:

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Technology Process of (3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

There total 11 articles about (3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104708-02-3
2-Methyl-2-(S)-oxiranyl-propan-1-ol

: 215317-79-6
(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / imidazole / CH₂Cl₂ / 2.5 h

2: 72 percent / 1,2-dimethoxy-ethane; hexane / Heating

3: 81 percent / LiHMDS / tetrahydrofuran / -78 °C

4: 96 percent / LDA / tetrahydrofuran / 2 h / -78 °C

5: 99 percent / Dibal-H / CH₂Cl₂ / -78 °C

6: 93 percent / TiCl₄ / benzene / 0.5 h

7: 94 percent / TBAF / tetrahydrofuran

8: 89 percent / camphorsulfonic acid / benzene / 6 h / Heating

9: 73 percent / Dibal-H / CH₂Cl₂; hexane / 0 - 20 °C

10: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 to -40 deg C, 40 min

With 1H-imidazole; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; titanium tetrachloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; benzene;
DOI:10.1021/jo981083t

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 215317-79-6
(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / camphorsulfonic acid / benzene / 6 h / Heating

2: 73 percent / Dibal-H / CH₂Cl₂; hexane / 0 - 20 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 to -40 deg C, 40 min

With oxalyl dichloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In hexane; dichloromethane; benzene;
DOI:10.1021/jo981083t

Reference yield:

: 215317-76-3
(3R,5R)-5-m-dithian-2-yl-2,2-dimethyl-1,3-hexanediol

: 215317-79-6
(3R,5R)-5-[1,3]Dithian-2-yl-3-(4-methoxy-benzyloxy)-2,2-dimethyl-hexanal

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / camphorsulfonic acid / benzene / 6 h / Heating

2: 73 percent / Dibal-H / CH₂Cl₂; hexane / 0 - 20 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 to -40 deg C, 40 min

With oxalyl dichloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In hexane; dichloromethane; benzene;
DOI:10.1021/jo981083t