(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Base Information

Chemical Name:(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate
CAS No.:1363479-09-7
Molecular Formula:C₂₆H₂₇N₃O₁₀S₂
Molecular Weight:605.646
Hs Code.:

Synonyms:(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

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Chemical Property of (E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

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Technology Process of (E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

There total 10 articles about (E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1363480-55-0
(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

: 1363479-09-7
(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;
DOI:10.1021/jm201717y

Reference yield: 44.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1363480-47-0
(7-(N-(2-hydroxyethyl)sulfamoyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

: 1363479-09-7
(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; for 10h;
DOI:10.1021/jm201717y

Reference yield:

: 1214876-52-4
(3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)-methyl methanesulfonate

: 1363479-09-7
(E)-(7-(N-(2-hydroxyethyl)sulfamoyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / dichloromethane / 12 h / -78 - 15 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / 1 h / 0 °C

3: sulfuric acid; potassium nitrate / 0.33 h / -5 - 0 °C

4: dichloromethane / 0.25 h / 0 °C

5: water; caesium carbonate / methanol / 0.25 h / 0 °C

6: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 10 h

With chlorosulfonic acid; oxalyl dichloride; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y