(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Base Information

Chemical Name:(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate
CAS No.:1363480-55-0
Molecular Formula:C₃₁H₃₅N₃O₁₁S₂
Molecular Weight:689.764
Hs Code.:

(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Synonyms:(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

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Chemical Property of (E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

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Technology Process of (E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

There total 9 articles about (E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1363480-49-2
(5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

: 1363480-55-0
(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: With EDCI*TsOH; toluene-4-sulfonic acid; In dichloromethane; for 6h;
DOI:10.1021/jm201717y

Reference yield:

: 2201-20-9
2-[(tetrahydropyran-2-yl)oxy]ethylamine

: 1363480-55-0
(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0.25 h / 0 °C

2: water; caesium carbonate / methanol / 0.25 h / 0 °C

3: EDCI*TsOH; toluene-4-sulfonic acid / dichloromethane / 6 h

With EDCI*TsOH; water; caesium carbonate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1021/jm201717y

Reference yield:

: 885226-91-5
1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1363480-55-0
(E)-(3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-7-(N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)sulfamoyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: sodium iodide / butanone / 17 h / 85 °C

2: acetonitrile / 24 h / Darkness

3: chlorosulfonic acid / dichloromethane / 12 h / -78 - 15 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / 1 h / 0 °C

5: sulfuric acid; potassium nitrate / 0.33 h / -5 - 0 °C

6: dichloromethane / 0.25 h / 0 °C

7: water; caesium carbonate / methanol / 0.25 h / 0 °C

8: EDCI*TsOH; toluene-4-sulfonic acid / dichloromethane / 6 h

With chlorosulfonic acid; oxalyl dichloride; sulfuric acid; EDCI*TsOH; water; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; sodium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; butanone;
DOI:10.1021/jm201717y