(4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
• CAS No.: 181716-29-0
• Molecular Formula: C₃₅H₅₃NO₄
• Molecular Weight: 551.81

Synonyms:(4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property of (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 12 articles about (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2,2-dimethoxy-propane (77-76-9) + {(1S,2S,4R)-5-Benzyloxy-1-[3-(4,4-dimethyl-pentyl)-benzyl]-2-hydroxy-4-methyl-pentyl}-carbamic acid tert-butyl ester → (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (181716-29-0)

Guidance literature:

Ambient temperature;

DOI:10.1016/S0960-894X(96)00279-X

Reference yield:

1,3-dimethanol benzene (626-18-6) → (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (181716-29-0)

Guidance literature:

Multi-step reaction with 13 steps

1: 50 percent / imidazole / CH₂Cl₂

2: 90 percent / MnO₂ / CHCl₃ / Heating

3: 81 percent / n-BuLi / tetrahydrofuran

4: TBAF / tetrahydrofuran

5: H₂ / Pd/C

6: 88 percent / NBS, PPh₃ / CH₂Cl₂ / Ambient temperature

7: 1.) n-BuLi, 2.) HCl, H₂O / 1.) THF, 2.) MeCN

8: NaOH / H₂O; dioxane

9: NaOH / H₂O

10: HNMeOMe, NMM

11: LiAlH₄ / diethyl ether

12: Mg / diethyl ether / 0 °C

13: 73 percent / Ambient temperature

With 4-methyl-morpholine; 1H-imidazole; hydrogenchloride; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; water; hydrogen; magnesium; triphenylphosphine; N,0-dimethylhydroxylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; chloroform; water;

DOI:10.1016/S0960-894X(96)00279-X

Reference yield:

3-(tert-Butyldimethylsiloxymethyl)benzyl Alcohol (81805-53-0) → (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (181716-29-0)

Guidance literature:

Multi-step reaction with 12 steps

1: 90 percent / MnO₂ / CHCl₃ / Heating

2: 81 percent / n-BuLi / tetrahydrofuran

3: TBAF / tetrahydrofuran

4: H₂ / Pd/C

5: 88 percent / NBS, PPh₃ / CH₂Cl₂ / Ambient temperature

6: 1.) n-BuLi, 2.) HCl, H₂O / 1.) THF, 2.) MeCN

7: NaOH / H₂O; dioxane

8: NaOH / H₂O

9: HNMeOMe, NMM

10: LiAlH₄ / diethyl ether

11: Mg / diethyl ether / 0 °C

12: 73 percent / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; tetrabutyl ammonium fluoride; water; hydrogen; magnesium; triphenylphosphine; N,0-dimethylhydroxylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; chloroform; water;

DOI:10.1016/S0960-894X(96)00279-X

upstream raw materials:

2,2-dimethoxy-propane

1,3-dimethanol benzene

3-(tert-Butyldimethylsiloxymethyl)benzyl Alcohol

[3-(4,4-Dimethyl-pentyl)-phenyl]-methanol

Downstream raw materials:

(4S,5S)-5-((R)-2-Butylcarbamoyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(4S,5S)-5-((R)-2-Carboxy-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(2R,4S,5S)-5-Amino-6-[3-(4,4-dimethyl-pentyl)-phenyl]-4-hydroxy-2-methyl-hexanoic acid butylamide

(4S,5S)-4-[3-(4,4-Dimethyl-pentyl)-benzyl]-5-((R)-3-hydroxy-2-methyl-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 181716-29-0 (4S,5S)-5-((R)-3-Benzyloxy-2-methyl-propyl)-4-[3-(4,4-dimethyl-pentyl)-benzyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send