5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

Base Information

Chemical Name:5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole
CAS No.:1410082-26-6
Molecular Formula:C₂₅H₂₄F₂N₆S
Molecular Weight:478.569
Hs Code.:

Synonyms:5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

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Chemical Property of 5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

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Technology Process of 5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

There total 7 articles about 5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.1%

: 1410082-25-5
4-(4-fluorophenyl)-5-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl)-4H-1,2,4-triazole-3-thiol

: 1410082-26-6
5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

Guidance literature:: With sulfuric acid; at 20 ℃; Cooling with ice;
DOI:10.1134/S106816201205010X

Reference yield:

: 1410082-22-2
N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

: 1410082-26-6
5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 3 h / Reflux

2: sulfuric acid / 20 °C / Cooling with ice

With sulfuric acid; sodium hydroxide; In ethanol; water;
DOI:10.1134/S106816201205010X

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1410082-26-6
5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 3 h / Reflux

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 6 h / Reflux

3: triethylamine / tetrahydrofuran / 0 - 20 °C

4: hydrazine hydrate / ethanol / 8 h / Reflux

5: ethanol / 6 h / Reflux

6: sodium hydroxide / ethanol; water / 3 h / Reflux

7: sulfuric acid / 20 °C / Cooling with ice

With sulfuric acid; palladium on activated charcoal; hydrazine hydrate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1134/S106816201205010X