N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

Base Information

Chemical Name:N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide
CAS No.:1410082-22-2
Molecular Formula:C₂₅H₂₆F₂N₆OS
Molecular Weight:496.584
Hs Code.:

Synonyms:N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

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Chemical Property of N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

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Technology Process of N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

There total 4 articles about N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 1410082-19-7
2-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetohydrazide

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1410082-22-2
N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

Guidance literature:: In ethanol; for 6h; Reflux;
DOI:10.1134/S106816201205010X

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1410082-22-2
N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Reflux

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 6 h / Reflux

3: triethylamine / tetrahydrofuran / 0 - 20 °C

4: hydrazine hydrate / ethanol / 8 h / Reflux

5: ethanol / 6 h / Reflux

With palladium on activated charcoal; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; butan-1-ol;
DOI:10.1134/S106816201205010X

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 1410082-22-2
N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3 h / Reflux

2: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 6 h / Reflux

3: triethylamine / tetrahydrofuran / 0 - 20 °C

4: hydrazine hydrate / ethanol / 8 h / Reflux

5: ethanol / 6 h / Reflux

With palladium on activated charcoal; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; butan-1-ol;
DOI:10.1134/S106816201205010X