1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

Base Information

Chemical Name:1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one
CAS No.:328546-77-6
Molecular Formula:C₁₇H₁₅N₃O₂
Molecular Weight:293.325
Hs Code.:

Synonyms:1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

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Chemical Property of 1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

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Technology Process of 1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

There total 8 articles about 1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 124-40-3
dimethyl amine

: 328542-61-6
3-(6-oxo-6,7,8,9-tetrahydro-2,7,9a-triaza-benzo[cd]azulen-1-yl)-benzaldehyde

: 328546-77-6
1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

: 1-(3-Dimethylaminomethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 3h; pH=6;
DOI:10.1021/jm0255769

Reference yield: 5.5%

: 328542-61-6
3-(6-oxo-6,7,8,9-tetrahydro-2,7,9a-triaza-benzo[cd]azulen-1-yl)-benzaldehyde

: 328546-77-6
1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

: 1-(3-Dimethylaminomethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

Guidance literature:: With hydrogenchloride; NaBH₃CN; dimethyl amine; zinc(II) chloride; In methanol;

Reference yield:

: 5337-09-7
2-bromo-3-nitro-benzoic acid methyl ester

: 328546-77-6
1-(3-Hydroxymethyl-phenyl)-8,9-dihydro-7H-2,7,9a-triaza-benzo[cd]azulen-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / N,N-dimethyl-acetamide / 4.5 h / 100 °C

2: H₂; acetic acid / Pd/C / ethyl acetate / 2585.81 Torr

3: 81 percent / NaHSO₃ / N,N-dimethyl-acetamide / 2 h / 100 °C

4: conc. H₂SO₄ / methanol; H₂O / 5 h / Heating

5: 5.5 percent / NaCNBH₃; ZnCl₂; HCl / methanol / 3 h / 20 °C / pH 6

With hydrogenchloride; sulfuric acid; hydrogen; sodium cyanoborohydride; sodium hydrogensulfite; acetic acid; zinc(II) chloride; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide; water; ethyl acetate;
DOI:10.1021/jm0255769